Breadcrumb Home > Thesaurus > T Synonyms of trephine Find synonyms for: Noun 1. trepan, trephine, surgical instrument usage: a surgical instrument used to remove sections of bone from the skull Verb 1. trephine, operate on, operate usage: operate on with a trephine WordNet 3.0 Copyright © 2006 by Princeton University. All rights reserved.Definition and meaning of trephine (Dictionary) TrendingHere are the facts and trivia that people are buzzing about. Hanukkah Origins of the Christmas Holiday Jewish Holidays, 2010-2030 (A.M. 5770-5791) Western Christian Holidays, 2010-2030 Krampus: The Christmas Devil Kwanzaa ✖ Related Content Daily Word Quiz: frisson Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language