Teams earn three points for a win and one point for a tie; first team to earn five points advances.
| Date | Result |
|---|
| Sept. 25 | at Dallas 4, Colorado 2 |
| Sept. 28 | at Colorado 1, Dallas 0 |
| Oct. 2 | Colorado 1, at Dallas 1 |
| | (Colorado advances in a series tiebreaker overtime after Game 3) |
| Date | Result |
|---|
| Sept. 25 | Columbus 2, at San Jose 1 |
| Sept. 28 | at Columbus 2, San Jose 1 |
| | (Columbus wins series, 6 points to 0) |
| Date | Result |
|---|
| Sept. 26 | at New England 2, Chicago 0 |
| Sept. 29 | at Chicago 2, New England 1 |
| Oct. 2 | at New England 2, Chicago 0 |
| | (New England wins series, 6 points to 3) |
| Date | Result |
|---|
| Sept. 25 | at Los Angeles 3, Kansas City 2 (OT) |
| Sept. 28 | at Kansas City 4, Los Angeles 1 |
| Oct. 2 | at Los Angeles 5, Kansas City 2 |
| | (Los Angeles wins series, 6 points to 3) |
MLS Playoffs
MLS Playoffs: Semifinals
