Breadcrumb Home > Dictionary > Index D depopulate: Meaning and Definition of Find definitions for: de•pop•u•late Pronunciation: (v.dē-pop'yu-lāt"adj.dē-pop'yu-lit, -lāt"), [key] — v., adj. -lat•ed, -lat•ing, —v.t. to remove or reduce the population of, as by destruction or expulsion. —adj. depopulated. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: depopulate (Thesaurus) Depo-Provera deport TrendingHere are the facts and trivia that people are buzzing about. Jewish Holidays, 2010-2030 (A.M. 5770-5791) Western Christian Holidays, 2010-2030 12 Steps to a New Year New Year's Resolution to Slim Down? Martin Luther King Speeches Books of the Bible: Old Testament Books in Order ✖ Related Content Daily Word Quiz: rapacious Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language